Shout has been doing good with sales from what I understand via the site. They'll most likely concentrate on putting out the single seasons (S1.1, S1.2, etc) instead of marketing this.
That being said, I could see them re-releasing it after all the seasons have been put out. But leaving something out or adding something new.
I think this is likely going to be the case. The single season sets will likely come out one at a time for mass retail, then a box set that will be different from this online/SDCC exclusive. This is the most likely given the potential for them to double dip on the hardcore collectors. Lucaas has been doing that for years.
I'm not a big toon fan, never really felt it did the property justice even as a kid, but I did enjoy some of the episodes, so I would like to get the seasons, but only if I can get them for relatively cheap. I don't need a super-duper box set, so hopefully I'll be able to pick up the episodes down the line for a decent price.
For toon fans though it is nice to see such a nicely put together set.